This volume brings together a distinguished, international list of scholars to explore the role of the learner's intention in knowledge change. Traditional views of knowledge reconstruction placed the impetus for thought change outside the learner's control. The teacher, instructional methods, materials, and activities were identified as the seat of change. Recent perspectives on learning, however, suggest that the learner can play an active, indeed, intentional role in the process of knowledge restructuring. This volume explores this new, innovative view of conceptual (...) change learning using original contributions drawn from renowned scholars in a variety of disciplines. The volume is intended for scholars or advanced students studying knowledge acquisition and change, including educational psychology, developmental psychology, science education, cognitive science, learning science, instructional psychology, and instructional and curriculum studies. (shrink)

Our paper ‘A new cosmological argument’ gave an argument for the existence of God making use of the weak Principle of Sufficient Reason (W-PSR) which states that for every proposition p, if p is true, then it is possible that there is an explanation for p. Recently, Graham Oppy, as well as Kevin Davey and Rob Clifton, have criticized the argument. We reply to these criticisms. The most interesting kind of criticism in both papers alleges that the W-PSR can be (...) justifiably denied by the atheist, and constitutes no improvement on the strong Principle of Sufficient Reason (S-PSR) which claims that every true proposition in fact has an explanation. The criticism is predicated on the fact that it can be shown that the W-PSR entails the S-PSR. We argue that the W-PSR's plausibility remains despite the criticisms. From this it can be seen to follow that the entailment relation between the W-PSR and the S-PSR gives one reason to believe the S-PSR. (shrink)

The employment of mythological language and imagery by an Epicurean poet - an adherent of a system not only materialist, but overtly hostile to myth and poetry - is highly paradoxical. This apparent contradiction has often been ascribed to a conflict in the poet between reason and intellect, or to a desire to enliven his philosophical material with mythological digressions. This book attempts to provide a more positive assessment of Lucretius' aims and methodology by considering the poet's attitude to myth, (...) and the role which it plays in the De Rerum Natura, against the background of earlier and contemporary views. The author suggests that Lucretius was not only aware of the tension between his two roles as philosopher and poet, but attempted to resolve it by developing his own, Epicurean poetic, together with a bold and innovative theory of the origins and meaning of myth. (shrink)

John Conington was a towering figure in Victorian scholarship, not least because of his remarkably sensitive and literate commentaries on Virgil’s _Aeneid. _The three-volume cloth edition of _The Works of Virgil_, begun by Conington in 1852, has been unavailable for over a century, except in rare second-hand sets. Now, for the first time, the whole of Conington’s work is being reissued in a set of six paperback volumes. Each volume includes a new introduction by an established scholar, setting Conington's commentary (...) in context, as well as a general introduction to Conington’s work by Philip Hardie, who offers a fresh appreciation of the work. (shrink)

The overwhelming importance of Lucretius' De Rerum Natura for the interpretation of the Georgics is recognized by almost all critics. As W. Y. Sellar expressed it over a hundred years ago, ‘the influence, direct and indirect, exercised by Lucretius on the thought, composition and even the diction of the Georgics was perhaps stronger than that ever exercised, before or since, by one poet on the work of another’. Richard Thomas' recent commentary attempts to play down the extent of this influence, (...) contending that ‘the debt of Virgil to Lucretius in the Georgics is predominantly formal’, and manifests itself chiefly on a verbal level, whereby the poet seeks ‘to create a didactic appearance for his poem’. The aim of this paper is to reassert the pervasive importance of Lucretian ideas, as well as Lucretian language, throughout the poem, and particularly in Virgil's presentation of the physical and metaphysical relationships between man and beast. (shrink)

This chapter contains sections titled: * Incoherency Objections * Objections to Theistic Arguments * Empirical Arguments a gainst God’s Existence * References * Further Reading.

R. M. Adams’s essay, “Must God Create the Best?” can be interpreted as offering a theodicy for God’s creating morally less perfect beings than he could have created. By creating these morally less perfect beings, God is bestowing grace upon them, which is an unmerited or undeserved benefit. He does so, however, in advance of the free moral misdeeds that render them undeserving. This requires that God have middle knowledge, pace Adams’s version of the Free Will Theodicy, of what would (...) result from his actualization of possible free persons. It is argued that God’s possession of such middle knowledge negates the freedom of created beings, since God completely determines every action of every created person. And since they are not free, they cannot qualify as morally unmeritorious or undeserving. And, with that, Adams’s theodicy of grace-in-advance collapses. (shrink)

In simplified form, the argument that I am defending holds that the incompatibility of our freedom with determinism follows from the conjunction of (1) a plausible supervenience claim which says that whether a human agent is free depends only on what happens during the agent’s life and (2) a freedom-cancellation principle of Richard Gale which says that an agent is not free if all of her actions are intentionally brought about by another agent. Improved versions of (1) and (2) are (...) also considered. (shrink)

In a series of articles, the most extensive of which are [9] and [10], Carl R. Kordig has attacked the "new empiricism" of the late Norwood R. Hanson, P. K. Feyerabend, Thomas S. Kuhn, and Stephen E. Toulmin. While there are differ- ences among the views of these philosophers, they agree at least on the following claims: (1) scientific method does not proceed inductively from neutral observations because (a) observations are not free of interpretation; and (b) scientists, as a matter (...) of history, have not used induction as the means of arriving at scientific laws; and (2) the key to scientific progress is the discovery of theories, hypotheses, or paradigms which order phenomena and influence the ways in which data are experienced. While Kordig admits that the new empiricism has the valuable effect of underscoring the truth that scientific revolutions do not consist merely in finding new facts or in paying closer attention to already known facts, contrary to the new view, he maintains that observations must be and are neutral ([9], pp. 478-479). Kordig contends against the new empiricists that if observations are not neutral but theory-laden, then it is impossible to test, compare and verify theories. Conse- quently, Kordig concludes that the new empiricist view implies that scientific progress is impossible ([9], pp. 470-471; [10j, p. 470). In opposition to their view, Kordig maintains that observations are neutral and independent of theories (and this was the insight of the logical empiricists) ([10], p. 468); and moreover, observa- tions must be neutral to and independent of theory in order that (a) differing theories may be truly said to compete and (b) the observations may be the basis of testing and deciding between competing theories. (shrink)

Idealogically motivated responses to the Bishops' Letter have heightened the divisiveness of subsequent dialogue at the expense of its rigor. Schumpeter's metaphor of creative destruction provides a vehicle for reconciliation between advocates of politics and markets. His most distinguishing characteristic of capitalism extols its productive and dynamic properties. It underscores its relentless and unmanageable side that transforms institutional structures as well. The capitalist engine is driven by a perennial gale that creates and destroys at the same time; thus there is (...) a necessary role for both entrepreneurs and planners in a mixed economy. The bishops' call for collaboration is also subject to the Schumpeterian metaphor. Major process changes without new institutional forms are inconsistent with the historical experience of U.S. pluralist society. (shrink)

Adhering to the traditional concept of omniscience lands Gale in the incoherence Grim’s Cantorian arguments reveal in talk of “all propositions.” By constructing variants and extensions of Grim’s arguments, I explain why various ways out of the incoherence are unacceptable, why theists would do better to adopt a certain revisionary concept of omniscience, and why the Cantorian troubles are so deep as to be troubles as well for Gale’s Weak PSR. I conclude with some brief reflections on method, suggesting that (...) we pursue the full implications of Gale’s own revisionary remarks and replace his method of analytic argumentation with non-analytic revisionary theory-construction. (shrink)

Cortical stimulation has been used for brain mapping for over a century, and a standard assumption is that stimulation interferes with task execution due to local effects at the stimulation site. Stimulation can however produce afterdischarges which interfere with functional localization and can lead to unwanted seizures. We previously showed that cognitive effort can terminate these afterdischarges, when termination thus occurs, there are electrocorticography changes throughout the cortex, not just at sites with afterdischarges or sites thought functionally important for the (...) cognitive task used, and thresholds for afterdischarges and functional responses can change among stimulation trials. We here show that afterdischarge termination can occur prior to overt performance of the cognitive tasks used to terminate them. These findings, taken together, demonstrate that task-related brain changes are not limited to one or a group of functional regions or a specific network, and not limited to the time directly surrounding overt task execution. Discrete locations, networks and times importantly underpin clinical behaviors. However, brain activity that is diffuse in location and extended in time also affect task execution and can affect brain mapping. This may in part reflect fluctuating levels of attention, engagement, or motivation during testing. (shrink)

One of the greatest of modern philosophers, on a par with his contemporary John Locke, Leibniz was born in Leipzig in 1646, died in Hanover in 1716. He was a leading figure in European intellectual circles, and the founder of the Academy of Berlin. His strange, complex metaphysical system established him as the third of the great 'Rationalists', after Descartes and Spinoza. Along with the 'New System', his most famous philosophical works are the Discourse of Metaphysics and Monadology. He also (...) made important contributions to logic, mathematics, theology, jurisprudence, and history.Gathered here for the first time are all the key texts in a crucial debate in modern philosophy, centred on Leibniz's famous 1695 essay, the `New System of the Nature of Substances and their Communication'. In this classic essay Leibniz introduced to a broad European readership the strikingly original metaphysical ideas he had come to a decade earlier. His 'system' became increasingly famous and drew him into discussion and development of these ideas, both in public and in private, with a variety of thinkers: Simon Foucher; Henri Basbage de Beauval; Francois Lamy; Isaac Jacquelot; the Englishwoman Damaris Masham; Pierre Desmaizeaux; René Joseph de Tournemine; and most notably the great French philosopher and scholar Pierre Bayle. (shrink)

R. S. Peters on Education and Ethics reissues seven titles from Peters' life's work. Taking an interdisciplinary approach, the books are concerned with the philosophy of education and ethics. Topics include moral education and learning, authority and responsibility, psychology and ethical development and ideas on motivation amongst others. The books discuss more traditional theories and philosophical thinkers as well as exploring later ideas in a way which makes the subjects they discuss still relevant today.

Brock Macdonald1, Evi Vakiani2, Rhonda K Yantiss3, Jun Lee4, Robert S Brown Jr5, Samuel H Sigal61Division of Gastroenterology, Department of Medicine, University of California-San Francisco, San Francisco, CA, 2Department of Pathology, Memorial Sloan–Kettering Cancer Center, New York, NY, 3Department of Pathology and Laboratory Medicine, New York Weill Cornell Medical College, New York, NY, 4Division of Nephrology, Department of Medicine, Weill Cornell Medical College, New York, NY, 5Division of Gastroenterology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, (...) NY, 6Division of Gastroenterology and Hepatology, Department of Medicine, New York University, New York, NY, USA: The use of sirolimus as an alternative to calcineurin inhibitors for posttransplant immunosuppression is associated with a variety of inflammatory conditions. In this report, we describe the case of a 34-year-old man who developed abnormal liver tests 6 years after live-donor kidney transplantation and 5 years after initiation of sirolimus-based immunosuppression. Elevated aminotransferase levels persisted after withdrawal of potentially hepatotoxic medications, and serologic evaluation for viral hepatitis, autoimmune disease, and genetic disorders was unrevealing. Liver biopsy revealed prominent hepatocellular injury associated with a mixed inflammatory infiltrate and liver tests normalized within 2 weeks of discontinuation of sirolimus. In this report, we review previous reports of sirolimus hepatotoxicity and propose a unifying hypothesis for the various inflammatory conditions that have been attributed to sirolimus.Keywords: sirolimus, immunosuppression, transplant, inflammatory conditions, hepatotoxicity. (shrink)